I’d say a great deal of caution is always called for when using any duplicate remover–making sure you have adequate backups, etc. I’d also be extra careful trying to remove duplicates using a 3rd party tool for files stowed under systems other than the Finder, such as Mail, Photos, Music, DevonThink, EagleFiler, etc.–so careful, in fact, that I personally would avoid doing it as much as possible.
My large scale duplicate removals have been restricted to files stowed only under the Finder, and even then, on a carefully selected basis, limiting scope as much as possible.
For anyone still looking for further duplicate analysis tools, I just came across Duplicate Detective. I’ve not used it, so this isn’t a recommendation, but might be of interest…
