Undestood, but nevertheless, periodic black-outs like this indicate a loss of sync. Usually, this is the cables, although it is certainly possible that there’s a problem with the computer or the display.
Unfortunately, proper testing of a cable (to generate an eye pattern diagram for analysis) requires specialized equipment that is too expensive to buy if you’re not in the business of manufacturing or certifying equipment.
Another possibility could be EMI.
I have seen plenty of occasions where getting a static shock from a metal surface (usually during the winter) near an HDMI-connected device caused the picture to momentarily black-out.
I also know that USB-3 cables have been known to interfere with Bluetooth. I haven’t heard of it interfering with HDMI, but cable-to-cable interference is not without precedent.
So, if you’ve got a rats-nest of cables behind your computer, maybe see if organizing/moving them helps. If EMI proves to be an issue, consider cables with heavier shielding.
I have a studio filled with Mac Studios and Dell monitors on campus. This is a constant issue. I turn on and off the Dell monitor if one of them fails to come on and it works.
I want to echo @tommy’s comment. Very similar situation here. Seen it plenty of times between Macs and Dell monitors here at the lab (not trying to say it’s an issue with Dell monitors — we just have a lot of them because they’re good screens). Even if we use quality DP or HDMI cables instead of USB->whatever cables or make sure there are no TB hubs in between, it always ended up happening from time to time. Usually turning the monitor on/off (like @tommy suggests) or opening/closing the MB lid revived external output.
I will say though that, for me, since I upgraded my main work MBP to an M4 Pro, I have yet to see the problem appear, this is with my trusty old Dell U2720Q.