FWIW, my backup devices (yes, I know, only three of them) are Toshiba 4TB N300 NAS drives. I’m using them in generic USB 3.0 enclosures, not in a NAS.
They work well, but I found that I needed to get enclosures with cooling fans, because they run too hot for a passive-cooling enclosure, and they pretty much stop working when they overheat. I suspect this will be the case for all 7200 RPM and high capacity drives.