Aside from the Finder failing to open the Preview and MS Word apps when double-clicking Preview and MS Word file icons after startup, my biggest beef with “Big Slow” is slowness of the Finder.
I have several folder aliases in my dock. When I click one of them, the folder’s files and sub-folders are displayed. When I hover over one of these sub-folders, the Finder is extremely slow to display that sub-folder’s contents. This continues down through the folder hierarchy.
This extreme slowness did not occur in Catalina, which displayed sub-folder’s contents virtually instantaneously.
Reinstalling Big Sur did not fix this issue.
I’m using a 27-inch Retina iMac Late 2015 with 24 GB of RAM and 2 TB of storage.
I haven’t had a spinning boot drive since c. 2014 on any Mac, but I have not noticed any slowness in Big Sur at all. Some beta bugs when I have the betas installed, but otherwise it’s been very solid for me. Annoying and fiddly at times, but speedy and stable.
That would be the next thing I’d try. It’s a hassle, but if it’s not a hardware issue causing the slowdown, there’s a good chance some piece of installed software is causing it. A clean reinstall, restoring your data, and then reinstalling your apps is the best way to see if it’s a software issue. If you’ve not been able to find the cause of the slowness some other way, this is probably the next thing you need to do unfortunately.